A bone scan in September 1987 documented increased activity in the sternum and two right anterior ribs consistent with metastatic disease.
X-ray studies confirmed probable sternum metastases. Since she had developed recurrent disease while receiving aggressive chemotherapy, FK began investigating alternative approaches to cancer.
Usually, it takes multiple mutations over a lifetime to cause cancer.This is why cancer occurs more often in older people who have had more opportunities for mutations to build up.She learned of my work and first came to my office in December 1987, while she still continued chemotherapy.At that time, she complained of fatigue and severe depression, particularly worse after each dose of chemotherapy.You inherit one set of chromosomes from your mother and one set from your father.
One chromosome in each set of 23 determines whether you are female or male.She was referred for a breast biopsy, which proved to be benign.However, within a month of the procedure, her health began to decline rapidly: she developed gradually worsening fatigue, paresthesias and chronic wheezing.Therefore, each gene must have the correct instructions or "code" for making its protein.This is so the protein can perform the correct function for the cell.Depending on where in the gene the change occurs, a mutation may be beneficial, harmful, or make no difference at all.